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作为Hi-C和CUT&Tag技术的合体版，HiCuT技术相对于同类技术减少了对样本量的需求量，可获得高分辨率的空间互作，且极大降低了测序深度。使用HiCuT研究蛋白介导的DNA互作，联合ATAC-seq和RNA-seq，或GWAS风险位点等多组学信息，可以深入解析基因表达的表观调控机制。

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